https://doi.org/10.4081/rp.2023.796
The perinatal period as a delicate time of transition. The possible implications of maternal stress in relation to cancer onset in intrauterine life
Submitted: March 21, 2023
Accepted: June 7, 2023
Published: December 19, 2023
Accepted: June 7, 2023
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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The perinatal period represents not only a transitional phase but a set of processes with respect to which both mother and child, whom she carries in her womb, are exposed to a series of factors capable of bringing about significant morphological and epigenetic changes. While these are, on the one hand, promoters of neurobiological and psychic changes, on the other, they confirm the presence of a real intrauterine exchange which, depending on the mother’s background, is capable of translating into neurochemical baggage ready to be transmitted to the fetus. In fact, while the latter, from a genetic point of view inherits a parental heritage, vice versa from an epigenetic point of view it will acquire a morphological and behavioral framework correlated with a future adaptive and/or dysfunctional mode of expression. Maternal health therefore reflects a psychic and biological condition which, during pregnancy, can bring about considerable changes in the fetus as a reflection of its own way of being in the world. Therefore, the presence of a dysfunctional emotional self-regulation mode in pregnancy, if cumulative, can lead in the long term to the onset of a chronic and/or repetitive stress condition, which risks affecting at a biological level an internal portion of chromatin and more specifically the length of telomeres. These consequently affect the possible increase in DNA methylation related to the possible onset of carcinogenesis.
Barker, D.J. (1995). The fetal origins of adult disease. Proceedings of the Royal Society of London Series B: Biological Sciences.
Biava, P.M., et al. (2001). J Tumor Marker Oncol 16:203-206.
Blaze, J., Asok, A., Roth, T.L. (2015). The long term impact of adverse caregiving environments on epigenetic modifications and telomeres. Frontiers in Behavioral Neuroscience.
DOI: https://doi.org/10.3389/fnbeh.2015.00079
Bottaccioli, F. (2020). Psiconeuroendocrinoimmunologia e scienza della cura integrata. Edra edizioni S.p.a, Milano.
DOI: https://doi.org/10.3280/PNEI2019-002011
Champagne, F.A., Curley, J.P. (2009). The trans-generational fluence of maternal care on offspring gene expression and behavior in rodents, Maternal effects in mammals. Maestripieri & Mateo Ed., Chicago.
DOI: https://doi.org/10.7208/chicago/9780226501222.003.0009
Crews, D., Gillette, R., Skinner, M.K. (2014). Nature, nurture, and epigenetics. Cell Endocrinol.
DOI: https://doi.org/10.1016/j.mce.2014.07.013
D’Amore, C. (2019). Come proteggere la mente che nasce. Armando Editore, Roma.
Doll, R., Peto, R. (1981). The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. Int J Cancer 1191-1308.
DOI: https://doi.org/10.1093/jnci/66.6.1192
Dujits S.F., Zeegers, M.P. (2003). The association between stressful life events and breast cancer risk: a meta- analysis. Int J Cancer 1023-1029.
DOI: https://doi.org/10.1002/ijc.11504
Eng J.W.L., Kokolous, K.M. (2014). A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response. Cancer Immunol Immunother 1115-1128.
DOI: https://doi.org/10.1007/s00262-014-1617-9
Entringer, S., Epel, E.E. (2011). Stress exposure in intrauterine life is associated with shorter telomere lenght in young adulthood. PNAS 108.
DOI: https://doi.org/10.1073/pnas.1107759108
Epel, E.S., Blackburn, E.H. (2004). Accelerated telomere shortening in response to life stress, Pediatrics 554-565.
Issa, J.P. (1997). Alterations in DNA Methylation: A fundamental aspect of Neoplasia. Advances in Cancer Research, Volume 72, pp. 141-182, 182a, 182b, 183-196.
DOI: https://doi.org/10.1016/S0065-230X(08)60702-2
Kelly-Irving, M., Lepage, B. (2013). Childhood adversity as a risk for cancer: findings from the 1985 British birth cohort study. BMC Public Health 76-80.
DOI: https://doi.org/10.1186/1471-2458-13-767
Kolb, B., Gibb, R. (2011). Brain plasticity and behaviour in the developing brain. J Can Acad Child Adolesc Psychiatry 2011.
Kroenke, C., Epel, E., Adler, N. (2011). Autonomic and adrenocortical reactivity and buccal cell telomere lenght in kindergarten children. Psychosomatic Medicine 533-540.
DOI: https://doi.org/10.1097/PSY.0b013e318229acfc
Lillberg, K., Verkasalo, P.K. (2003). Stressful life event s and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol 415-423.
DOI: https://doi.org/10.1093/aje/kwg002
Liu, J., Lester, B.M. (2013). Regional brain morphometry and impulsivity in adolescents following prenatal exposure to cocaine and tobacco. JAMA Pediatric 167:348-354.
DOI: https://doi.org/10.1001/jamapediatrics.2013.550
Marafante, D. (2012). Cancro tra mente e corpo. Edizioni Riza, Milano.
Militello, C. (2022). Epigenetica. Come baci, carezze e coccole ti cambiano il DNA. Dissensi edizione, Firenze.
Olumi, A.F., Grossfeld G.D., Hayward, S.W., et al. (1999). Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res, 59:5002-50011.
Parkin, D.M., Boyd, L., Walker, L.C. (2011). The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010: Summary and conclusions. Br J Cancer 2011.
DOI: https://doi.org/10.1038/bjc.2011.489
Qin, J., Jin, F., Li, N. (2015). Adrenergic receptor β2 activation by stress promotes breast cancer progression through macrophages M2 polarization in tumor microenvironment. BMB Reports 295-300.
DOI: https://doi.org/10.5483/BMBRep.2015.48.5.008
Renan, M.J. (1993). How many mutations are required for tumorigenesis? Implications from human cancer data. Mol Carcinog 7:139-146.
DOI: https://doi.org/10.1002/mc.2940070303
Ridout, S.J., Ridout, K.K, Kao, H.T. (2015). Telomeres, early-life stress and mental illness. Adv Psychosom Med.
DOI: https://doi.org/10.1159/000369088
Shen, H., Laird, P.W. (2013). Interplay between the cancer genome and epigenome. Cell.
DOI: https://doi.org/10.1016/j.cell.2013.03.008
Siegel, D.J. (2017). La mente relazionale: neurobiologia dell’esperienza interpersonale. Raffaello Cortina, Milano.
Skobe, M., Fusening, N.E. (1998). Tumorigenic conversion of immortal human keratinocytes through stromal cell activation. Proc Nat Acad Sci USA 95;1050-1055.
DOI: https://doi.org/10.1073/pnas.95.3.1050
Thaker P, H., Han, L, Y., (2006). Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. In Nat Med: 939-994.
How to Cite
Marcí, C. (2023). The perinatal period as a delicate time of transition. The possible implications of maternal stress in relation to cancer onset in intrauterine life. Ricerca Psicoanalitica, 34(3). https://doi.org/10.4081/rp.2023.796
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